Headley hit a three-run home run to cap a six-run fifth inning that tied the game 7-7. His two-run blast in the seventh put San Diego ahead 9-8 after Rod Barajas had hit an RBI single for Pittsburgh in the sixth.
San Diego ran its winning streak to 10 games in Pittsburgh and hasnât lost at PNC Park since Sept. 18, 2009. The Padres have won five straight games overall.
H e a d leyâs goahead home run came off lefthander Tony Watson (5-2), who entered the game with two outs in the seventh inning and walked Everth Cabrera. Headley followed with his 17th homer.
Brad Brach (1-2) got his first major league win, allowing one run in two innings while striking out three. Huston Street pitched a 1-2-3 ninth for his 21st save in as many opportunities.
Alexi Amarista of the Padres had two hits and two RBIs, including a home run to lead off the game, his fifth. Travis Snider hit a threerun homer for the Pirates, his first since being acquired July 30 in a trade. Garrett Jones homered for the Pirates and Pedro Alvarez had two hits and two RBIs.
The teams traded big innings while batting around with San Diego scoring six runs in the fifth off James McDonald to tie the game 7-7 after Pittsburgh had a five-run fourth.
Headleyâs three-run homer knocked McDonald from the game. Pinch-hitter Jesus Guzman hit a two-run double and scored on Amaristaâs single before Headleyâs blast to center field.
The Pirates got their five runs in the fourth on Sniderâs three-run home run and Alvarezâs two-run single.
McDonaldâs second-half woes continued as he was tagged for seven runs and seven hits in 4 1-3 innings. He is 1-2 with an 8.71 ERA in six starts since the All-Star break after going 9-3 with a 2.37 ERA in 17 firsthalf starts.
San Diego starter Edinson Volquez didnât make it out of the fourth inning as he was charged with six runs in 3 1-3 innings while allowing seven hits and four walks with three strikeouts. He has a 13.50 ERA in his last three starts, giving up 15 runs in 10 innings after going 3-0 with a 1.55 ERA in his previous six starts.
After Amarista gave the Padres a 1-0 lead, the Pirates moved in front as Starling Marte singled home a run in the second and Jones homered in the third.
Notes: San Diego rookie C Yasmani Grandal, on the DL with a strained oblique, hit off a tee before the game and is expected to take batting practice on the field Saturday. The Padres, though, have yet to set a timetable for his return. . Because of the spacious left-field gap at PNC Park, Padres manager Bud Black had LF Will Venable and RF Carlos Quentin switch positions. . RHP A.J. Burnett (14-3, 3.19) will try to become Pittsburghâs first 15-game winner since Todd Ritchie in 1999 when he pitches against San Diego RHP Jason Marquis (5-6, 4.10) on Saturday night. Burnett has won 13 of his last 14 decisions and Marquis has won four of his last five starts.